PTF home
Mechanisms, Methods and Malignancies (M3)


Mechanisms, Methods and Malignancies (M3) is the sixth of 8 interdepartmental blocks in the medical school curriculum taking place in the fall of the second preclinical year. This block uses a multidisciplinary approach to teach the molecular basis of cancer and provide a framework for understanding its clinical management. UCSF Postdoctoral Teaching Fellows will help teach the topics in cell and molecular biology, genetics, and pharmacology through 6 two-hour small-group sessions that focus on clinical applications of the basic sciences.

The topics of the discussion sessions include: cell cycle, oncogenes and tumor suppressor genes, DNA damage and repair, molecular diagnostics, biochemical basis of chemotherapy and pharmacogenetics.

* Prior to the start of the block, teaching fellows will participate in two preparatory sessions: a general orientation to the block and small group teaching, and a hands-on session in which fellows practice small group teaching techniques with actual students.

* Before each small-group session, teaching fellows and faculty will meet to review the content of the session and to develop teaching strategies. After each teaching session, the faculty and teaching fellows will meet to compare experiences and share ideas.

* During the block, teaching fellows will attend lectures and collaborate with faculty on the design and grading of examinations.

*  Teaching fellows will have the option of developing and implementing course innovations such as web-based self-assessment modules or small-group discussion exercises.

M3 teaching dates occur between October and December. The dates of the orientation and small group meetings will be announced soon.

In each small-group session, students work cooperatively to solve a problem set. You may download one example problem set and the related syllabyus chapters by clicking the links below. Note that the problem sets and syllabus sections for this year will be revised, but will contain similar content.

These documents contain copyrighted material.
Reproduction for anything other than educational purposes is a violation of U.S. copyright laws.

M3 Problem Set

Cellular Proliferation and its Regulation

Tumor Suppressor Genes and Oncogenes


Questions? Contact Dr. Katherine Hyland in the Dept. of Biochemistry & Biophysics.