The O'Farrell Lab at UCSF

Banff National park, Canadian Rockies

  I started working with flies as an undergrad and never left. I've worked on habituation, replication- and DNA damage-checkpoints, size control in development and engulfment of apoptotic cells. In the O'Farrell Lab I've focussed on nitric oxide synthase and innate immune responses. I can also be found adding "u"s to words like "colour" and employing the use of the lac-zed system. When I'm not in the lab, I love to hike, camp, rock-climb, travel and take lots of pictures.
Bachelor of Science
Master of Science
Post-doctoral Fellow
Simon Fraser University, Burnaby, Canada
University of Alberta, Edmonton, Canada
London Research Institute Cancer Research UK and University College London, London, UK
Laboratory for Molecular Cell Biology (Medical Research Council), London, UK
Liz's Publications
  1. Yakubovich N, Silva EA, O'Farrell PH. Nitric oxide synthase is not essential for Drosophila development. Curr Biol. 2010 Feb 23;20(4):R141-2.
  2. Sopko R, Silva E, Clayton L, Gardano L, Barrios-Rodiles M, Wrana J, Varelas X, Arbouzova NI, Shaw S, Saburi S, Matakatsu H, Blair S, McNeill H. Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown. Curr Biol. 2009 Jul 14;19(13):1112-7.
  3. Cuttell L, Vaughan A, Silva E, Escaron CJ, Lavine M, Van Goethem E, Eid JP, Quirin M, Franc NC. Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasis. Cell. 2008 Oct 31;135(3):524-34.
  4. Silva EA, Burden J, Franc NC. In vivo and in vitro methods for studying apoptotic cell engulfment in Drosophila. Methods Enzymol. 2008;446:39-59.
  5. Silva E, Au-Yeung HW, Van Goethem E, Burden J, Franc NC. Requirement for a Drosophila E3-ubiquitin ligase in phagocytosis of apoptotic cells. Immunity. 2007 Oct;27(4):585-96.
  6. Silva EA, Lee BJ, Caceres LS, Renouf D, Vilay BR, Yu O, Bradley JA, Campbell SD. A novel strategy for identifying mutations that sensitize Drosophila eye development to caffeine and hydroxyurea. Genome. 2006 Nov;49(11):1416-27.
  7. Silva E, Tsatskis Y, Gardano L, Tapon N, McNeill H. The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway. Curr Biol. 2006 Nov 7;16(21):2081-9.
  8. Sharma P, Asztalos Z, Ayyub C, de Bruyne M, Dornan AJ, Gomez-Hernandez A, Keane J, Killeen J, Kramer S, Madhavan M, Roe H, Sherkhane PD, Siddiqi K, Silva E, Carlson JR, Goodwin SF, Heisenberg M, Krishnan K, Kyriacou CP, Partridge L, Riesgo-Escovar J, Rodrigues V, Tully T, O'Kane CJ. Isogenic autosomes to be applied in optimal screening for novel mutants with viable phenotypes in Drosophila melanogaster. J Neurogenet. 2005 Apr-Jun;19(2):57-85.
  9. Silva E, Tiong S, Pedersen M, Homola E, Royou A, Fasulo B, Siriaco G, Campbell SD. ATM is required for telomere maintenance and chromosome stability during Drosophila development. Curr Biol. 2004 Aug 10;14(15):1341-7.
  10. Radcliffe CM, Silva EA, Campbell SD. A method for assaying the sensitivity of Drosophila replication checkpoint mutants to anti-cancer and DNA-damaging drugs. Genome. 2002 Oct;45(5):881-9.
  11. Sinclair DA, Schulze S, Silva E, Fitzpatrick KA, Honda BM. Essential genes in autosomal heterochromatin of Drosophila melanogaster. Genetica. 2000;109(1-2):9-18.
  12. Schulze S, Sinclair DA, Silva E, Fitzpatrick KA, Singh M, Lloyd VK, Morin KA, Kim J, Holm DG, Kennison JA, Honda BM. Essential genes in proximal 3L heterochromatin of Drosophila melanogaster. Mol Gen Genet. 2001 Feb;264(6):782-9.
  13. Singh M, Silva E, Schulze S, Sinclair DA, Fitzpatrick KA, Honda BM. Cloning and characterization of a new theta-class glutathione-S-transferase (GST) gene, gst-3, from Drosophila melanogaster. Gene. 2000 Apr 18;247(1-2):167-73.