The O'Farrell Lab at UCSF
  • B.S School of Life Sciences, University of Science & Technology of China (2000-2004);
  • Ph.D Dept. of Molecular and Cell Biology (Lab of Cellular Dynamics), University of Science & Technology of China (2004-2010);
  • Postdoc Dept. of Biochemistry and Biophysics, UCSF (2010-present).

Kai's Publications
  1. Yuan K, O'Farrell PH. (2015). Cyclin B3 is a mitotic cyclin that promotes the metaphase-anaphase transition. Curr Biol In Press.
  2. Yuan K, Shermoen AW, O'Farrell PH. (2014). Illuminating DNA replication during Drosophila development using TALE-lights. Curr Biol 24(4):R144-145.
  3. Farrell JA, Shermoen AW, Yuan K, O'Farrell PH. (2012). Embryonic onset of late replication requires Cdc25 down-regulation. Genes Dev 26:714-725.
  4. Yuan K, Farrell JA, O'Farrell PH. (2012). Different cyclin types collaborate to reverse the S-phase checkpoint and permit prompt mitosis. J Cell Biol 198(6):973-980.
  5. Yuan K, Huang Y, Yao X. (2011). Illumination of mitotic orchestra during cell division: A polo view. Cell Signal 23(1):1-5.
  6. Wang C, Yu J, Yuan K, Lan J, Jin C, Huang H. (2010). Plk1-mediated mitotic phosphorylation of PinX1 regulates its stability. Eur J Cell Biol 89(10):748-756.
  7. Yuan K, Li N, Jiang K, Zhu T, Huo Y, Wang C, Lu J, Shaw AP, Thomas K, Zhang J, Mann D, Liao J, Jin C, Yao X. (2009). PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation. J Biol Chem 284(34):23072-23082.
  8. Yuan K*, Li N*, Huo Y, Yan F, Yang Y, Ward T, Jin C, Yao X. (2009). Recruitment of separase to mitotic chromosomes is regulated by Aurora B. Cell Cycle 8(9):1433-1443. * equal contribution
  9. Li N, Yuan K, Yan F, Yang Y, Ward T, Jin C, Yao X. (2009). PinX1 is recuited to the mitotic chromosome periphery by Nucleolin and facilitates chromosome congression. Biochem Biophys Res Commun 384(1):76-81.
  10. Yuan K*, Hu H*, Guo Z, Fu G, Shaw AP, Hu R, Yao X. (2007). Phospho-regulation of HsCDC14A by polo-like kinase 1 is essential for mitotic progression. J Biol Chem 282(37):27414-27423. * equal contribution
  11. Fu G, Ding X, Yuan K, Aiknionbare F, Yao J, Cai X, Jiang K, Yao X. (2007). Phosphorylation of human Sgo1 by Nek2A is essential for chromosome congression in mitosis. Cell Res 17(7):608-18.