The O'Farrell Lab at UCSF
Jennifer Page

    My project is to understand how mitochondrial DNA (mtDNA) is inherited through the female germline in Drosophila melanogaster. We know that in Drosophila, mtDNA is inherited exclusively from the mother, but the mechanisms by which mitochondria are included in the germ line as it is formed during early embryogenesis is still unclear. My work focuses on the establishment of the future germ line during oogenesis and embryogenesis, following the fate of mitochondria at various stages and analyzing the interactions of various maternal gene products with mitochondria. From this, we will better understand how the female fly uses oogenesis to distribute mitochondrial DNA to her offspring.

    I studied Biological Sciences at Clemson University in Clemson, SC. While there, I worked in the lab of Dr. Julia Frugoli to look at the role of auxin signaling during nodulation in the model legume Medicago truncatula. For my Ph.D., I joined the lab of Dr. Robert Weiss at Cornell University. There, I worked on understanding the mechanisms of regulation of ribonucleotide reductase in mice.

Jenn's Publications
  1. Page, JL, X Xu, E Ylikallio, M Li, J Levy, RM Peters, A Suomalainen, and RS Weiss. Mammalian ribonucleotide reductase is governed btwo primary regulatory mechanisms that prevent lethal alterations in nucleotide levels. In preparation.
  2. Ylikkalio,E †, JL Page †, X Xu, M Lampinen, G Bepler, T Ide, H Tyynismaa, RS Weiss, and A Suomalainen. Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice. Nucleic Acids Research. E-pub August 20, 2010.

    † Co-first authors

  3. Selvaraj, V1, A Asano1, JL Page2, JL Nelson1, KSD Kothapalli3, JA Foster4, JT Brenna3, RS Weiss2 and AJ Travis1. Mice lacking FABP9/PERF15 develop sperm head abnormalities but are fertile. Developmental Biology.
  4. Xu, X, JL Page, JA Surtees, H Liu, S Lagedrost, Y Lu, R Bronson, E Alani, AY Mikitin, and RS Weiss. Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms. Cancer Research, 68:2652-60, 2008.
  5. Mueller, JL, JL Page, and MF Wolfner. An ectopic expression screen reveals the protective and toxic effects of Drosophila seminal fluid proteins. Genetics, 175:777-83. 2007.