guthrie lab publications

Guthrie Lab Publications — 1985 - present


 
  indexed by date
 
 

    2010 - present

  1. Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase Activity. Ledoux S & Guthrie C. J Biol Chem. 2016. Apr 12. pii: jbc.M115.710848. [Epub ahead of print]. PMID: 27072132.

  2. Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing. Mayerle M & Guthrie C. RNA. 2016 May;22(5):793-809. PMID: 26968627.

  3. A new communication hub in the RNA world. Mayerle M & Guthrie C. NSMB. 2016. Mar 2;23(3):189-90.PMID: 26931416.

  4. Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough. Holmes RK, Tuck AC, Zhu C, Dunn-Davies HR, Kudla G, Clauder-Munster S, Granneman S, Steinmetz LM, Guthrie C, Tollervey D. PLoS Genet. 2015. 11(2):e1005735. PMID: 26694144.

  5. SR protein kinases promote splicing of nonconsensus introns. Lipp JJ, Marvin MC, Shokat KM, Guthrie C. Nat Struct Mol Biol. 2015. 22(8):611. PMID: 26167880.

  6. Genetic interaction mapping reveals a role for the SWI/SNF nucleosome remodeler in spliceosome activation in fission yeast. Patrick KL, Ryan CJ, Xu J, Lipp JJ, Nissen KE, Roguev A, Shales M, Krogan NJ, Guthrie C. PLoS Genet. 2015. 11(3):e1005074. PMID: 25825871.

  7. Present at the creation. Guthrie C. RNA. 2015. 21(4):481. PMID: 25780103.

  8. Genetic interaction analysis of point mutations enables interrogation of gene function at a residue-level resolution: exploring the applications of high-resolution genetic interaction mapping of point mutations. Patrick KL, Ryan CJ, Xu J, Lipp JJ, Nissen KE, Roguev A, Shales M, Krogan NJ, Guthrie C. PLoS Genet. 2015. 11(3):e1005074. PMID: 25825871.

  9. Adventures in time and space: splicing efficiency and RNA polymerase II elongation rate. Moehle EA, Braberg H, Krogan NJ, Guthrie C. RNA Biol. 2014. 11(4):313-9. PMID: 24717535.

  10. The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing. Hadjivassiliou H, Rosenberg OS, Guthrie C. RNA. 2014. 20(5):656-69. PMID: 24681967.

  11. H2B ubiquitylation modulates spliceosome assembly and function in budding yeast. Hérissant L, Moehle EA, Bertaccini D, Van Dorsselaer A, Schaeffer-Reiss C, Guthrie C, Dargemont C. Biol Cell. 2014. 106(4):126-38. PMID: 24476359.

  12. Preparation of fluorescent pre-mRNA substrates for an smFRET study of pre-mRNA splicing in yeast. Abelson J, Hadjivassiliou H, Guthrie C. Methods Enzymol. 2013. 533:43-55. PMID: 24182917.

  13. Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing. Krishnan R, Blanco MR, Kahlscheuer ML, Abelson J, Guthrie C, Walter NG. Nat Struct Mol Biol. 2013. 20(12):1450-7. PMID: 24240612.

  14. An unanticipated early function of DEAD-box ATPase Prp28 during commitment to splicing is modulated by U5 snRNP protein Prp8. Price AM, Görnemann J, Guthrie C, Brow DA. RNA. 2014. 20(1):46-60. PMID: 24231520.

  15. Yeast-gene replacement using PCR products. Bergkessel M, Guthrie C, Abelson J. Methods Enzymol. 2013. 533:43-55. PMID: 24182917.

  16. Chemical transformation of yeast. Bergkessel M, Guthrie C. Methods Enzymol. 2013. 529:311-20. PMID: 24011057.

  17. Colony PCR. Bergkessel M, Guthrie C. Methods Enzymol. 2013. 529:299-309. PMID: 24011056.

  18. From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II. Braberg H, Jin H, Moehle EA, Chan YA, Wang S, Shales M, Benschop JJ, Morris JH, Qiu C, Hu F, Tang LK, Fraser JS, Holstege FC, Hieter P, Guthrie C, Kaplan CD, Krogan NJ. Cell. 2013. 154(4):775-88. PMID: 23932120.

  19. The yeast SR-like protein Npl3 links chromatin modification to mRNA processing. Moehle EA, Ryan CJ, Krogan NJ, Kress TL, Guthrie C. PLoS Genet. 2012. 8(11):e1003101. PMID: 23209445.

  20. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman JI, Jiang L, Kuo D, Tosti E, Kim HS, Edelmann W, Keogh MC, Greene D, Tang C, Cunningham P, Shokat KM, Cagney G, Svensson JP, Guthrie C, Espenshade PJ, Ideker T, Krogan NJ. Mol Cell. 2012. 46(5):691-704. PMID: 22681890.

  21. Diverse forms of RPS9 splicing are part of an evolving autoregulatory circuit. Plocik AM, Guthrie C. PLoS Genet. 2012 Mar;8(3):e1002620. Epub 2012 Mar 29. PMID: 22479208.

  22. Diverse environmental stresses elicit distinct responses at the level of pre-mRNA processing in yeast. Bergkessel M, Whitworth GB, Guthrie C. RNA. 2011. 17(8):1461-78. PMID: 21697354. PMID: 21697354 [PubMed - as supplied by publisher].

  23. Regulation of the Dbp5 ATPase cycle in mRNP remodeling at the nuclear pore: a lively new paradigm for DEAD-box proteins. Ledoux S, Guthrie C. Genes Dev. 2011 Jun 1;25(11):1109-14. PMID: 21632821 [PubMed - in process]

  24. Huff JT, Plocik AM, Guthrie C, Yamamoto KR.Reciprocal intronic and exonic histone modification regions in humans. Nat Struct Mol Biol.2010 Dec;17(12):1495-9. [PubMed - indexed for MEDLINE]

  25. Mitrovich QM, Tuch BB, De La Vega FM, Guthrie C, Johnson AD.Evolution of yeast noncoding RNAs reveals an alternative mechanism for widespread intron loss. Science. 2010 Nov 5;330(6005):838-41. [PubMed - indexed for MEDLINE]

  26. Abelson J, Hadjivassiliou H, Guthrie C. Preparation of fluorescent pre-mRNA substrates for an smFRET study of pre-mRNA splicing in yeast.Methods Enzymol. 2010;472:31-40.[PubMed - indexed for MEDLINE]

  27. Abelson J, Blanco M, Ditzler MA, Fuller F, Aravamudhan P, Wood M, Villa T, Ryan DE, Pleiss JA, Maeder C, Guthrie C, Walter NG. Conformational dynamics of single pre-mRNA molecules during in vitro splicing. Nat Struct Mol Biol. 2010 Apr;17(4):504-12. Epub 2010 Mar 21.[PubMed - indexed for MEDLINE]

  28. Guthrie C. (2010) From the ribosome to the spliceosome and back again. J Biol Chem. 285(1):1-12.[Pubmed citation].

  29. John Abelson, Mario Blanco, Mark A. Ditzler, Franklin Fuller, Pavithra Aravamudhan, Mona Wood, Tommaso Villa, Daniel E. Ryan, Jeffrey A. Pleiss, Corina Maeder, Christine Guthrie, Nils G. Walter (2010) Conformational dynamics of single pre–mRNA molecules during in vitro splicing. Nat Struct Mol Biol. 2010. 17(4):504-12. PMID: 20305654.

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    2005 - 2009

  31. John Abelson (2009) From molecular biology to geology: a surprising trajectory. J Biol Chem. 25;284(52):35997-6006. PMID: 19854832 [PubMed - indexed for MEDLINE][Pubmed citation].

  32. Zhang L, Xu T, Maeder C, Bud LO, Shanks J, Nix J, Guthrie C, Pleiss JA, Zhao R. (2009) Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2. Nat Struct Mol Biol. 16(7):731-9.[Pubmed citation].

  33. Wilmes GM, Guthrie C. (2009) Getting to the gate: crystallization of a Sac3(CID):Sus1:Cdc31 complex. Mol Cell 33(6):671-2.[Pubmed citation].

  34. Bergkessel M, Wilmes GM, Guthrie C. (2009) SnapShot: Formation of mRNPs. Cell. 136(4):794, 794.e1. [Pubmed citation].

  35. Maeder C, Kutach AK, Guthrie C. (2009) ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8. Nat Struct Mol Biol 16(1):42-8.[Pubmed citation].

  36. Wilmes GM, Bergkessel M, Bandyopadhyay S, Shales M, Braberg H, Cagney G, Collins SR, Whitworth GB, Kress TL, Weissman JS, Ideker T, Guthrie C, Krogan NJ. (2008) A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell 32(5):735-46[Pubmed citation].

  37. Kress, T.L., Krogan, N.J. and Guthrie, C. (2008) A single SR-like protein, Npl3, promotes pre-mRNA splicing in budding yeast. Mol Cell 32(5):727-34.[Pubmed citation].

  38. Maeder, C. and Guthrie, C. (2008) Modifications target spliceosome dynamics. Nat Struct Mol Biol. 15(5):426-8. [Pubmed citation].

  39. Lund, M.K., Kress, T.L. and Guthrie, C. (2008) Autoregulation of Npl3, a yeast SR protein, requires a novel downstream region and serine phosphorylation. Mol Cell Biol. 28(11):3873-81. [Pubmed citation]

  40. Mitrovich, Q.M. and Guthrie, C. (2007) Evolution of small nuclear RNAs in S. cerevisiae, C. albicans, and other hemiascomycetous yeasts. RNA 13: 2066-80. [Pubmed citation]

  41. Pleiss, J., Whitworth, G., Bergkessel, M. and Guthrie, C. (2007) Rapid, transcript-specific changes in splicing in response to environmental stress. Mol. Cell  27, 928–937. [Pubmed citation]

  42. Pleiss, J., Whitworth, G., Bergkessel, M. and Guthrie, C. (2007) Defects in essential spliceosomal components differentially affect splicing in a transcript-specific manner. PLoS Biol 5(4): e90. [Pubmed citation]

  43. Mitrovich, Q., Tuch, B.B., Guthrie, C. and Johnson, A.D. (2007) Computational and experimental approaches double the number of known introns in Candida alibcans. Genome Res. 17:492-502. [Pubmed citation]

  44. Kim-Guisbert, K., Li, H. and Guthrie, C. (2006) Alternative 3’ end processing in Saccharomyces cerevisiae is modulated by Nab4/Hrp1. PLoS Biol. 2006 Dec: 5(1):e6 [Pubmed citation]

  45. Kress. T and Guthrie, C. (2006) Accurate RNA “siting” and splicing gets help from a DEK-hand (Perspective) Science 312:1886-1887 [Pubmed citation].

  46. Preker, P. and Guthrie, C. (2006) Autoregulation of the mRNA export factor Yra1p requires inefficient splicing of its pre-mRNA. RNA 12: 994-106. [Pubmed citation]

  47. Brenner, T. and Guthrie, C. (2006). Assembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domain. RNA  12: 862-8 [Pubmed citation]

  48. Bellare, P., Kutach, A.K., Rines, A.K., Guthrie, C. and Sontheimer, E.J. (2005) Ubiquitin binding by a varant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p. RNA 12:292-302. [Pubmed citation]

  49. Lund, M. and Guthrie, C. (2005) The DEAD-box ATPase Dbp5 is required to dissociate Mex67p from exported mRNPs at the nuclear rim. Molec. Cell, 20(4):645-651 [Pubmed citation]

  50. Villa, T. and Guthrie, C. (2005) The Isy1p component of the NineTeen Complex interacts with the ATPase Prp16p to regualte the fidelity of pre-mRNA splicing. Genes and Dev., 19:1894-1904. [Pubmed citation]

  51. Guthrie, C. and Steitz, J. (2005) Nucleus and gene expression: Coordinated nuclear events regulate mRNA synthesis, processing, export and turnover. (Editorial Overview) Curr. Opin. Cell Biol., 17:239-241.

  52. Brenner, T. and Guthrie, C. (2005) Genetic analysis reveals a role for the C-terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activation. Genetics, 170:1063-1080. [ Pubmed Citation]

  53. Kim Guisbert, K., Duncan, K., Li, H., and Guthrie, C. (2005) Functional specificity of shuttling hnRNPs revealed by genome-wide analysis of their RNA binding profiles. RNA. [2005 Feb 9, Epub ahead of print]. [ Pubmed Citation] [Supplementary Information]


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    2000 - 2004

  55. Gilbert, W. and Guthrie, C. (2004) The Glc7p nuclear phosphatase promotes mRNA export by facilitating association of Mex67p with mRNA. Mol Cell, 13(2):201-12. [Pubmed Citation]

  56. Inada, M. and Guthrie, C. (2004) Identification of Lhp1p-associated RNAs by microarray analysis in Saccharomyces cerevisiae reveals association with coding and noncoding RNAs. PNAS, 101(2):434-9. Epub 2004 Jan 02. [Pubmed Citation]

  57. Rader, S.D. and Guthrie, C. (2002) A conserved Lsm-interaction motif in Prp24 required for efficient U4/U6 di-snRNP formation. RNA, 8(11):1378-92 [Pubmed citation]

  58. Preker, P.J., Kim, K.S. and Guthrie, C. (2002) Expression of the essential mRNA export factor Yra1p is autoregulated by a spicing-dependent mechanism. RNA, 8(8):969-80 [Pubmed citation]

  59. Villa, T., Pleiss, J.A. and Guthrie, C. (2002) Spliceosomal snRNAs: Mg(2+)-dependent chemistry at the catalytic core? Cell 109(2):149-52. [Pubmed citation]

  60. Collins, C.A. and Guthrie, C. (2001) Genetic interactions between the 5' and 3' splice site consensus sequences and U6 during the second catalytic step of pre-mRNA splicing. RNA 7(12):1845-54. [Pubmed citation]

  61. de Bruyn Kops, A. and Guthrie, C. (2001) An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport. EMBO J 20(15):4183-93. [Pubmed citation]

  62. Gilbert, W., Siebel, C.W. and Guthrie, C. (2001) Phosphorylation by Sky1p promotes Npl3p shuttling and mRNA dissociation., RNA, 7:1-12 [PubMed citation]

  63. Kistler, A.L., and Guthrie, C. (2001) Deletion of MUD2, the yeast homologue of U2AF65, can bypass the requirement for Sub2, an essential spliceosomal ATPase. Genes & Develop., 15:42-9. [PubMed citation]

  64. Collins, C. and Guthrie C. (2000) The question remains: Is the spliceosome a ribozyme? Nat. Struc. Biol. 7:850-854. [PubMed citation]


  65. Duncan, K., Umen, James G. and Guthrie, C.. (2000) A putative ubiquitin ligase required for efficient mRNA export differentially affects hnRNP transport. Current Biology 10: 687-696. [PubMed citation]


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    1995 - 1999

  67. Collins, C. and Guthrie, C. (1999) Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome. Genes & Develop. 13:1970-1982 [PubMed citation]


  68. Siebel, C.W., Feng, L., Guthrie, C. and Fu, X.-D. (1999) Conservation in budding yeast of a kinase specific for SR factors. Proc. Natl. Acad. Sci., 96: 5440-5445. [PubMed citation]


  69. Staley, J.P. and Guthrie, C. (1999) An RNA switch at the 5' splice site requires ATP and the DEAD-box protein Prp28p. Molec. Cell, 3: 55-64. [PubMed citation]


  70. Wang, Y. and Guthrie, C. (1998) Prp16, a DEAH-box RNA helicase, is recruited onto the spliceosome primarily via its non-conserved N-terminal domain. RNA, 4: 1216-1229. [PubMed citation]


  71. Ragunathan, P. and Guthrie, C. (1998) RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2. Curr. Biol., 8: 847-855. [PubMed citation]


  72. Wang, Y., Wagner, J. and Guthrie, C. (1998) Prp16, a DEAH-box splicing factor, unwinds RNA duplexes in vitro. Curr. Biol., 8: 441-451. [PubMed citation]


  73. Staley, J.P. and Guthrie, C. (1998) Mechanical devices in the spliceosome: Clocks, motors, springs and things. Cell, 92: 315-326. [PubMed citation]


  74. Raghunathan, P.L. and Guthrie, C. (1998) A spliceosomal recycling factor that reanneals U4 and U6 snRNPs. Science, 279: 857-860. [PubMed citation]


  75. Stade, K., Ford, C.S., Guthrie, C. and Weis, K. (1997) Exportin 1 (Crm1p) is an essential nuclear export factor. Cell, 90: 1041-1050. [PubMed citation]


  76. Chanfreau, G., Elela, S.A., Ares, M. and Guthrie, C. (1997) Alternative 3'-end processing of U5 snRNA by RNase III. Genes & Devel., 11: 2741-2751. [PubMed citation]


  77. Siebel, C.W. and Guthrie, C. (1996) The essential yeast RNA binding protein Np13p is methylated. Proc. Natl. Acad. Sci., 93: 13641-13646. [PubMed citation]


  78. Chanfreau, G., Noble, S.M. and Guthrie, C. (1996) An essential yeast protein with unexpected similarity to subunits of mammalian cleavage and polyadenylation specificity factor (CPSF). Science, 274: 1511-1514. [PubMed citation]


  79. Noble, S. and Guthrie, C. (1996) Transcriptional pulse-chase analysis reveals a role for a novel snRNP-associated protein in the manufacture of spliceosomal snRNPs. EMBO J, 15: 4368-4379. [PubMed citation]


  80. Noble, S. and Guthrie, C. (1996) Identification of novel components of the yeast pre-mRNA splicing machinery by means of cold-sensitive mutants. Genetics, 143: 67-80. [PubMed citation]


  81. Umen, J. and Guthrie, C. (1996) Mutagenesis of the yeast gene PRP8 reveals domains governing the specificity and fidelity of 3' splice site selection. Genetics, 143: 723-739. [PubMed citation]


  82. Guthrie, C. (1996) The spliceosome is a dynamic ribonucleoprotein machine. Harvey Lecture Series, 90: 59-80. [PubMed citation]


  83. Umen, J. and Guthrie, C. (1995) The second catalytic step of pre-mRNA splicing. RNA, 1: 869-885. [PubMed citation]


  84. Umen, J. G. and Guthrie, C. (1995) Prp16, Slu7 and Prp8 interact with the 3' splice site in two distinct stages during the second catalytic step of pre-mRNA splicing. RNA, 1:584-597. [PubMed citation]


  85. Jones, M.H., Frank, D.N., and Guthrie, C. (1995) Characterization and functional ordering of Slu7p and Prp17p during the second step of premRNA splicing in yeast. Proc. Natl. Acad. Sci., 92: 9687-9691. [PubMed citation]


  86. Jandrositz, A., and Guthrie, C. (1995) Evidence for a Prp24 binding site in U6 snRNA and in a putative intermediate in the annealing of U6 and U4 snRNAs. EMBO J., 14: 820-832. [PubMed citation]


  87. Umen, J. and Guthrie, C. (1995) A novel role for a U5 snRNP protein in 3' splice site selection. Genes & Develop. 9: 855-868. [PubMed citation]


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    1990 - 1994

  89. Madhani, H. and Guthrie, C. (1994) Dynamic RNA-RNA interactions in the spliceosome. Ann. Rev. Genet. 28: 1-26. [PubMed citation]


  90. Strauss, E. and Guthrie, C. (1994) PRP28, a "DEAD-box" protein, is required for the first step of mRNA splicing in vitro. Nucl. Acids Res. 22: 33187-3193. [PubMed citation]


  91. Madhani, H. and Guthrie, C. (1994) Randomization-selection analysis of snRNAs in vivo: Evidence for a tertiary interaction in the spliceosome. Genes & Devel. 8: 1071-1086. [PubMed citation]


  92. Madhani, H. and Guthrie, C. (1994) Genetic interactions betwen the RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase. Genetics, 137: 677-687. [PubMed citation]


  93. Frank, D., Roiha, H. and Guthrie, C. (1994) Architecture of the U5 snRNA. Mol. Cell. Biol. 14: 2180-2190. [PubMed citation]


  94. Lesser, C. and Guthrie, C. (1993) Mutations in U6 snRNA that alter splice site specificity: Implications for the active site. Science 262: 1982-1988. [PubMed citation]


  95. Burgess, S.M. and Guthrie, C. (1993) Beat the clock: Paradigms for NTPases in the maintenance of biological fidelity. Trends Biochem. Sci. 18: 381-384. [PubMed citation]


  96. Burgess, S.M and Guthrie, C. (1993) A mechanism for enhancing mRNA splicing fidelity by ATP hydrolysis: the RNA-dependent ATPase Prp16 governs usage of a discard pathway for aberrant lariat intermediates. Cell 73: 1377-1391. [PubMed citation]


  97. Lesser, C. F. and Guthrie C. (1993) Mutational analysis of pre-mRNA splicing in Saccharomyces cerevisiae using a sensitive new reporter gene, CUP1 . Genetics 133:851-863. [PubMed citation]


  98. Madhani, H. and Guthrie, C. (1992) A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome. Cell 71: 803-817. [PubMed citation]


  99. Schwer, B. and Guthrie, C. (1992) A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis. EMBO J.11: 5033-5039. [PubMed citation]


  100. Frank, D. and Guthrie, C. (1992) An essential splicing factor, SLU7, mediates 3’ splice-site choice in yeast. Genes & Devel. 6.: 2112-2124. [PubMed citation]


  101. Frank, D., Patterson, B. and Guthrie, C. (1992) Synthetic lethal mutations identify interactions between U5 snRNA and four proteins required for the second step of splicing. Mol. Cell. Biol. 21: 5197-5205. [PubMed citation]


  102. Schwer, B. and Guthrie, C. (1992) A dominant negative mutation in a splicesomal ATPase affects ATP hydrolysis, but not binding to the spliceosome. Mol. Cell. Biol. 12: 3540-3547. [PubMed citation]


  103. Bordonné, R. and Guthrie, C. (1992) Human and human-yeast chimeric U6 snRNA genes identify structural elements required for expression in yeast. Nucl. Acids Res. 20: 479-485. [PubMed citation]


  104. Siliciano, P.G., Kivens, W.J. and Guthrie, C. (1991) More than half of yeast U1 snRNA is dispensable for growth. Nucl. Acids Res. 19: 6367-6372. [PubMed citation]


  105. Guthrie, C. (1991) mRNA splicing in yeast: Clues to why the spliceosome is a ribonucleoprotein. Science 253: 157-163 . [PubMed citation]


  106. Shannon, K. and Guthrie, C. (1991) Suppressors of a U4 mutation define a novel U6 snRNP protein with RNA binding motifs. Genes & Develop. 5: 773-785. [PubMed citation]


  107. Strauss, E. and Guthrie, C. (1991) A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family. Genes & Develop. 5: 629-641. [PubMed citation]


  108. Schwer, B. and Guthrie, C. (1991) PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome. Nature 349: 487-493. [PubMed citation]


  109. Patterson, B. and Guthrie, C. (1991) A U-rich tract enhances usage of an alternative 3' splice site in yeast. Cell 64:181-187. [PubMed citation]


  110. Madhani, H., Bordonné, R. and Guthrie, C. (1990) Multiple roles for U6 snRNA in the splicing pathway. Genes & Develop. 4: 2264-2277. [PubMed citation]


  111. Jones, M.H. and Guthrie, C. (1990) Unexpected flexibility in an evolutionarily conserved protein:RNA interaction: Genetic analysis of the Sm binding site. EMBO J. 9: 2555-2561. [PubMed citation]


  112. Brow, D. and Guthrie, C. (1990) Transcription of the yeast U6 snRNA gene requires a pol III promoter element in a novel position. Genes & Develop. 4: 1345-1356. [PubMed citation]


  113. Bordonné, R., Banroques, J., Abelson, J. and Guthrie, C. (1990) Domains of yeast U4 spliceosomal RNA required for PRP4 protein binding, snRNP-snRNP interactions and pre-mRNA splicing in vivo. Genes & Develop. 4: 1185-1196. [PubMed citation]


  114. Shuster, E. and Guthrie, C. (1990) Human U2 snRNA can function in pre-mRNA splicing in yeast. Nature 345: 270-273. [PubMed citation]


  115. Burgess, S., Couto, J.R. and Guthrie, C. (1990) A putative ATP-binding protein influences the fidelity of branchpoint recognition in yeast splicing. Cell, 60: 705-717. [PubMed citation]


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    1985 - 1989

  117. Guthrie, C. (1989) Catalytic RNA and RNA splicing. Amer. Zoologist, 29: 557-567.

  118. Roiha, H., Shuster, E., Brow, D., and Guthrie, C.(1989) snRNAs from budding yeasts: Phylogenetic comparisons reveal extensive size variation. Gene, 82: 137-144. [PubMed citation]


  119. Brow, D.A. and Guthrie, C. (1989) Splicing a spliceosomal RNA. Nature, 337: 14-15. [PubMed citation]


  120. Siliciano, P. and Guthrie C. (1988) 5' splice site selection in yeast: genetic alterations in base pairing with U1 reveal additional requirements. Genes and Develop., 2: 1258-1267. [PubMed citation]


  121. Shuster, E. and Guthrie, C. (1988) Two conserved domains of yeast U2 snRNA are separated by 945 non-essential nucleotides. Cell, 55: 41-48. [PubMed citation]


  122. Guthrie, C. and Patterson, B. (1988) Spliceosomal snRNAs. Ann. Rev. Genetics, 22: 387-419. [PubMed citation]


  123. Brow, D. and Guthrie, C. (1988) Spliceosomal RNA U6 is remarkably conserved from yeast to mammals. Nature, 334: 213-218. [PubMed citation]


  124. Parker, R., Simmons, T., Shuster, E., Siliciano, P. and Guthrie, C. (1988) Genetic analysis of snRNAs in yeast: Viable sextuple mutant. Mol. Cell. Biol., 8: 3150-3159. [PubMed citation]


  125. Guthrie, C. (1987) Genetic analysis of yeast snRNAs. In: Structure and Function of Major and Minor snRNPs (ed. M. Birnstiel), Springer-Verlag, New York, pp. 196-211.

  126. Siliciano, P., Jones, M.H. and Guthrie, C. (1987) S. cerevisiae has a U1-like snRNA with unexpected properties. Science 237:1484-1487. [PubMed citation]


  127. Siliciano, P., Brow, D., Roiha, H. and Guthrie, C. (1987) An essential snRNA from S. cerevisiae has properties predicted for U4, including interaction with a U6-like snRNA. Cell 50: 585-592. [PubMed citation]


  128. Couto, J., Tamm, J., Parker, R. and Guthrie, C. (1987) A trans-acting suppressor restores splicing of a yeast intron with a branchpoint mutation. Genes & Develop. 1: 445-455. [PubMed citation]


  129. Patterson, B. and Guthrie, C. (1987). An essential yeast snRNA with a U5-like domain is required for splicing. Cell 49: 613-624. [PubMed citation]


  130. Parker, R., Siliciano, P., and Guthrie, C. (1987) Recognition of the TACTAAC box during mRNA splicing in yeast involves base-pairing with the U2-like snRNA. Cell, 49: 229-239. [PubMed citation]


  131. Riedel, N., Wolin, S., and Guthrie, C. (1987) A subset of yeast snRNAs contain functional binding sites for the highly conserved Sm antigen. Science, 235: 328-331. [PubMed citation]


  132. Guthrie, C. (1986) Finding functions for small nuclear RNAs in yeast. Trends Biochem. Sci. 11: 430-434.

  133. Riedel, N., Wise, J.A., Swerdlow, H., Mak, A. and Guthrie, C. (1986) Small nuclear RNAs from Saccharomyces cerevisiae: Unexpected diversity in abundance, size, and molecular complexity. Proc. Natl. Acad. Sci. 83: 8097-8101. [PubMed citation]


  134. Vijayraghavan, U., Parker, R., Tamm, J., Cellini, A., Rossi, J., Abelson, J. and Guthrie, C. (1986) Mutations in conserved signals affect multiple steps in the yeast splicing pathway, particularly assembly of the spliceosome. EMBO J. 5: 1683-1695. [PubMed citation]


  135. Cellini, A., Parker, R., McMahon, J., Guthrie, C. and Rossi, J. (1986) Activation of a cryptic TACTAAC box in the yeast actin intron. Mol. Cell. Biol., 6: 1571-1578. [PubMed citation]


  136. Guthrie, C., Riedel, N., Parker, R., Swerdlow, H., and Patterson, B. (1985) Genetic analyses of snRNAs and RNA processing in yeast. Yeast Cell Biology, UCLA Symposia on Molecular Biology, New Series, 33: 301-321.

  137. Tollervey, D. and Guthrie, C. (1985) Deletion of a yeast small nuclear RNA gene impairs growth. EMBO J. 4: 3873-3878. [PubMed citation]


  138. Parker, R. and Guthrie, C. (1985) A point mutation in the conserved hexanucleotide at the 5' splice junction of the yeast actin intron uncouples recognition, cleavage, and ligation. Cell 41: 107-118. [PubMed citation]


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